Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside

Name	BRD7552
Synonyms	CS-1560 BRD7552 BRD-7552 BRD 7552 Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate] ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
CAS	1137359-47-7

Molecular Formula	C33H33N3O15
Molar Mass	711.63
Density	1.53±0.1 g/cm3(Predicted)
Boling Point	757.6±60.0 °C(Predicted)
Solubility	DMSO: ≥ 38 mg/mL
pKa	11.81±0.20(Predicted)
Storage Condition	-20℃
In vitro study	BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells. BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner. Western Blot Analysis Cell Line: PANC-1 cells Concentration: 1.25, 2.5, 5 μM Incubation Time: 5 days Result: Induced a dose-dependent increase in PDX1 protein levels.

Last Update：2024-01-02 23:10:35

Biological activity	BRD7552 is a PDX1 transcription factor inducer, which upregulates the expression of PDX1 in primary human islets and ductal cells, and induces The epigenetic changes of the PDX1 promoter are consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreatic development and β-cell function.
in vitro study	BRD7552 (0-5μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells. BRD7552 acts in a FOXA2-dependent banner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10μM) cause a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner. Western Blot Analysis Cell Line: PANC-1 cells Concentration: 1.25, 2.5, 5 μ m Incubation Time: 5 days Result: Induced a pose-dependent increase in PDX1 protein levels.
Cell Line:	PANC-1 cells
Concentration:	1.25, 2.5, 5 μM
Incubation Time:	5 days
Result:	Induced a dose-dependent increase in PDX1 protein levels.

Last Update：2024-04-09 21:54:55

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Product Name: BRD7552 Visit Supplier Webpage Request for quotation
CAS: 1137359-47-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside Request for Quotation